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Life Sciences
Life scientists post their preprints on bioRxiv, and quantitative biology appears on arXiv too. This page shows the newest papers ReadSearch has read from both, from cell biology and genetics to neuroscience, ecology and immunology.
606 papers, from 31 August 2026 to 5 November 2026: 423 arXiv preprints, 128 bioRxiv preprints and 55 OpenAlex records.
Newest papers, page 13
MechGate: combining mechanism-derived measures of permeation and efflux to screen small molecule drugs targeting Escherichia coli
Most antibiotic molecules must cross the cell membrane and escape efflux pumps before hitting their targets.Sensorimotor behaviour from an untrained brain-and-nerve-cord connectome
Connectomes now map the neurons and synapses of an adult fly's brain and nerve cord, but how much of behaviour follows from the wiring is unknown.Multitask Interactions in Recurrent Dynamics across 100 Cognitive Tasks
The brain continually learns tasks with very different computational demands.Virtual Placebo: a scoping review of control conditions in randomized controlled trials of psychological immersive virtual reality interventions
Research on immersive virtual reality (IVR) as a therapeutic tool is growing rapidly, with randomized controlled trials (RCTs) now commonplace.Earth embeddings are decomposable records of the land surface
Ecological monitoring, carbon accounting and biodiversity assessment increasingly rely on annual Earth embeddings--learned vectors that compress a year of satellite observation for every ten-meter…What Transfers Across Protein Pockets? Experience Reuse in Molecular Optimization for Agentic Structure-Based Drug Design
LLM agents optimize a ligand in a protein pocket by editing it step by step and docking each edit.Computational De Novo Design of Miniprotein Candidate Neutralizers Targeting the IL-23 Cytokine Subunit p19
Interleukin-23 (IL-23) drives T-helper-17 inflammation underlying inflammatory bowel disease and psoriasis; anti-p19 antibodies are clinically effective but large, costly, and injectable.ZENO: Nonlinear filtering with Zakai Equation Neural Operators
State inference and parameter learning for nonlinear filters is a core computation for scientific machine learning with varied applications in engineering and neuroscience.Neural-DISCO: Source-Conditioned Counterfactual Editing of Neural Population Activity
Understanding how neural activity encodes behavioral and sensory variables is a key challenge in systems neuroscience.Agent-guided epitope excision enables economical de novo binder design
De novo protein design campaigns remain bottlenecked by the inference compute time required to generate and rank candidates, limiting wider functional exploration.Automated screening of Parkinson's Disease using Smooth Pursuit Eye Movements
Smooth pursuit eye movements are frequently altered in Parkinson's disease, but previous studies have relied mainly on conventional parameters that describe the relationship between gaze and target.Contact-Free Nuclear and Cytoplasmic Mechanophenotyping by Amplitude-Modulated Ultrasound and Phase-Locked Optical Diffraction Tomography: Computational Feasibility and Initial Experimental Readouts
We investigate whether acoustic stimulation combined with phase-locked optical diffraction tomography (ODT) could measure the mechanical responses of the nucleus and cytoplasm separately in adherent…Bistability with equal and independent removal in small bimolecular networks
We classify two-species mass-action networks with at most three internal directed reactions on $\{X,Y,2X,X+Y,2Y\}$, positive inflows, and linear removal of both species.Supercoiling Drives DNA-Protein Co-Condensation
The co-condensation of DNA and proteins plays an important role in genome compaction, including heterochromatin formation and chromosome segregation.RiboBridge: protein-conditioned de novo RNA binder structure design
Designing RNA molecules that bind to target protein structures requires generating both an RNA conformation and its bound complex geometry, without assuming a predefined binding site.Report the tolerance, not the count: exact phylogenetic distance deconvolution with incomplete references
Phylogenetic distance deconvolution represents mixture-to-reference distances by weighted sources placed on a reference tree.Global Convergence of Detailed Balanced Mass Action Systems
We give a self-contained proof that, for a finite detailed balanced mass-action system with positive rate constants, each positive stoichiometric compatibility class contains exactly one positive…Kinetic Proofreading Activation Times Beyond the Weibull Limit
T cells can detect a few foreign peptide-major histocompatibility complexes (pMHCs) among a far larger number of self pMHCs.A Mathematical Theory of the Jacobian Lens
Recent work from Anthropic introduced a new interpretability tool, called the Jacobian lens (J-lens, Gurnee et al., 2026).QUBO-Based Conformer Selection with Quantum-Classical Hybrid Optimization for Multiconformer Ligand Modeling
A ligand can adopt multiple conformations within the same binding site, and these conformations can interact differently with the surrounding protein.
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