PubMed ·
Antithrombotic Therapy in Patients with Chronic Coronary Disease on Anticoagulation: Evidence from Contemporary Trials.
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In brief
Navigating Antithrombotic Therapy in Heart Patients
This paper reviews contemporary trials and guidelines to clarify the best long-term treatment strategies for patients with CCD on anticoagulation. It emphasizes the effectiveness of OAC monotherapy and provides guidance on when to consider adding antiplatelet therapy.
What they found: The review highlighted that OAC monotherapy is effective in preventing major cardiovascular events while significantly reducing the risk of bleeding. Trials showed that this approach is noninferior to combination therapies in terms of ischemic protection. The findings suggest that OAC should be the default therapy for most patients, with antiplatelet therapy reserved for specific high-risk cases.
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From the abstract
Chronic coronary disease (CCD) commonly coexists with long-term oral anticoagulation (OAC), particularly for atrial fibrillation (AF). Combination antiplatelet therapy increases bleeding, whereas ischemic protection with OAC alone remains a concern.
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