PubMed ·
Diagnostic Agreement and Threshold Correspondence Between Resting Full-Cycle Ratio and Nicorandil-Based Fractional Flow Reserve in Intermediate Coronary Stenosis: A Prospective Single-Center Registry.
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In brief
Decoding Coronary Stenosis Measurements
This study sheds light on the agreement between RFR and nicorandil-based FFR in a cohort of 300 patients, revealing that while overall agreement is high, discrepancies are more pronounced near the FFR decision boundary.
What they found: The study found that RFR and nicorandil-based FFR demonstrated an overall agreement of 85.0%, with an impressive AUC of 0.932. However, discrepancies were notably higher near the FFR 0.80 threshold, with agreement dropping to 72.0%. This suggests that while RFR is a reliable measure, caution is needed in the critical zones where misalignment occurs.
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From the abstract
RFR has shown good aggregate agreement with FFR, including in prior Asian cohorts using intracoronary nicorandil. Where RFR-FFR disagreement is concentrated relative to the FFR 0.80 decision boundary, and how the two binary thresholds correspond, remain incompletely characterized.
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