PubMed ·
Cell Therapy for Heart Failure and Myocardial Infarction: Evidence Evolution and Translational Challenges Over Two Decades.
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In brief
Charting the Heart: Two Decades of Cell Therapy Research
This paper offers a comprehensive bibliometric analysis of 1,505 studies on cell therapy, revealing trends in research focus and highlighting the disconnect between animal and clinical studies. It provides a roadmap for future research priorities aimed at bridging this gap.
What they found: The analysis revealed a significant increase in research output from 34 articles in 2004 to a peak of 104 in 2012, followed by a decline to 49 in 2024. While animal studies remain robust, clinical research has sharply decreased, with only 4 studies published in 2024. The findings indicate a shift in focus from direct myocardial replacement to understanding mechanisms and optimizing delivery, yet persistent translational bottlenecks remain.
AI-written summary, not medical advice. Check anything you rely on against the original paper.
From the abstract
Cell-based myocardial repair has progressed from direct cell replacement toward paracrine, engineered tissue, and cell-free strategies, but the relationship between preclinical innovation and clinical translation remains unclear. We mapped the knowledge structure and translational trajectory of this field.
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