PubMed ·
Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy.
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In brief
Unlocking the Heart-Brain Connection
This review sheds light on the role of the autonomic nervous system (ANS) in inherited cardiac disorders, highlighting how it influences conditions like catecholaminergic polymorphic ventricular tachycardia and Brugada syndrome. By exploring the interplay between the heart and the nervous system, the authors propose new strategies for risk assessment and treatment.
What they found: The review highlights the critical role of the autonomic nervous system in inherited cardiac conditions like catecholaminergic polymorphic ventricular tachycardia and Brugada syndrome. It emphasizes that despite different genetic causes, these disorders share common pathophysiological features involving cardiac-modulating neurons. These insights could lead to improved risk stratification and treatment strategies for affected individuals.
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From the abstract
Inherited cardiac conditions are a leading cause of sudden cardiac death in young and otherwise healthy patients. They result from mutations in genes that encode proteins with various physiological functions.
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