PubMed ·
Repair and regeneration across the lifespan: an ontogenetic perspective.
- Published
- Source
- PubMed
- Published in
- Frontiers in Aging
- DOI
- 10.3389/fragi.2026.1888854
- Original
- Read it at PubMed
- Cited by
- 0 works, as OpenAlex counts them
- Topics
In brief
Rewiring Repair: Aging and Regeneration
This paper presents a comprehensive framework that maps the transition from embryonic regenerative capacity to the limitations seen in older adults. By reframing aging as a dynamic reallocation of biological resources, it opens new avenues for regenerative medicine that could enhance tissue repair and healthspan.
What they found: The review highlights how tissue repair capabilities decline significantly with age, often halving from youthful levels. It identifies key factors like stem cell exhaustion and chronic inflammation that contribute to this decline. The authors argue for a shift in regenerative medicine towards actively restoring tissue integrity rather than merely managing degeneration.
AI-written summary, not medical advice. Check anything you rely on against the original paper.
From the abstract
The capacity for tissue repair and regeneration undergoes a profound and progressive decline across the human lifespan, representing a fundamental driver of aging and chronic disease.
The opening of the authors’ abstract. The rest is with PubMed.
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